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Resuscitation-promoting Factors (Rpf): In Search of Inhibitors

[ Vol. 19 , Issue. 10 ]

Author(s):

Arseny S. Kaprelyants, Galina V. Mukamolova, Alessia Ruggiero, Vadim A. Makarov, Galina R. Demina, Margarita O. Shleeva, Vasilii D. Potapov and Pavel A. Shramko   Pages 1026 - 1034 ( 9 )

Abstract:


Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity.

Keywords:

Inhibitors, latency, nitrophenylthiocyanates, resuscitation, Rpf, tuberculosis, Mycobacterium tuberculosis, cell wall hydrolysing enzymes, therapeutic agents, molecular mechanisms

Affiliation:

A. N. Bach Institute of Biochemistry, RAS, Leninsky pr., 33, 119071, Moscow, Russia.



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