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Role of AQP4 Antibody Serostatus and its Prediction of Visual Outcome in Neuromyelitis Optica: A Systematic Review and Meta-Analysis

[ Vol. 24 , Issue. 3 ]


Nan Lin, Qing Liu, Xiaoyu Wang, Jianmei Ma and Yuyuan Li   Pages 245 - 252 ( 8 )


Backgroud: Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder, which is characterized by severe attacks of optic neuritis and myelitis. Antibodies (Ab) to aquaporin-4 (AQP4) (or NMO-IgG) as a serological biomarker of NMO have been widespread used. Nevertheless, some NMO patients remain seronegative for AQP4-Ab and/or have no detected optic nerve involvement. In addition, no consensus exists on the association between AQP4-Ab serostatus and visual outcome in NMO. To drive a more precise estimate of this postulated relationship, a metaanalysis was performed based on existing relevant studies.

Methods: Studies were searched by PubMed and MEDLINE up to March 2016. Study quality was assessed, and meta-analysis was conducted using the RevMan 5.1. Odds ratios with 95% confidence interval were calculated and funnel plot was applied to assess the potential publication bias.

Results: In a total of 1288 relevant studies, 18 studies satisfied the eligibility criteria and were included in the systemic review. Only 9 studies appeared eligible for the meta-analysis, together including 624 AQP4-Ab-positive and 119 AQP4-Ab-negative NMO patients. The results revealed associations between AQP4-Ab seropositivity and visual impairment in NMO (OR, 3.16; 95% CI, 1.09, 9.19; P = 0.03). The results of subgroup analyses based on different methods of AQP-4 detection also showed significantly differences between AQP4-Ab seropositivity and visual impairment in NMO, especially in CBA subgroup.

Conclusion: This meta-analysis indicates that AQP4-Ab serostatus has the positive with poor visual outcome in NMO.


Neuromyelitis optica, NMO, AQP4-Ab, NMO-IgG, serostatus, visual outcome, meta-analysis.


Department of Anatomy, Dalian Medical University, Western 9 Lvshunnan Road, Lvshun District, Dalian, 116044,, Advanced Institute for Medical Sciences, Dalian Medical University, Western 9 Lvshunnan Road, Lvshun District, Dalian, 116044

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