Submit Manuscript  

Article Details


When Good Goes Awry: The Aggregation of Protein Therapeutics

[ Vol. 24 , Issue. 4 ]

Author(s):

Jennifer M. Redington, Leonid Breydo and Vladimir N. Uversky   Pages 340 - 347 ( 8 )

Abstract:


Protein therapeutics are playing an increasingly important role in treatment of a variety of human diseases. However, like the rest of proteins, they are susceptible to aggregation. Aggregation of proteinaceous pharmaceuticals can cause a loss of efficacy and, potentially, cytotoxicity and an immunogenic response. This review describes various ways protein therapeutics aggregate and a variety of approaches taken to prevent or minimize this process.

Keywords:

Aggregation, formulation, storage, delivery, insulin, glucagon, antibodies

Affiliation:

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USF Health Byrd Alzheimer`s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, Department of Molecular Medicine Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC07, Tampa, Florida 33612

Graphical Abstract:



Read Full-Text article