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Brain Angiotensin II Involvement in Chronic Mental Disorders

[ Vol. 24 , Issue. 9 ]

Author(s):

Osvaldo Martin Basmadjian, Victoria Belen Occhieppo, Natalia Andrea Marchese, Gustavo Baiardi and Claudia Bregonzio*   Pages 817 - 826 ( 10 )

Abstract:


Background: The functioning of the central nervous system is complex and it implies tight and coordinated interactions among multiple components. Neurotransmitters systems imbalance is a hallmark in the central nervous system (CNS) disorders. These pathologies profoundly impact the social, cultural, and economic perspective worldwide. The etiopathology of CNS illnesses is still poorly understood, making their treatment difficult.

Brain angiotensin II (Ang II), through its AT1 receptors, modulates dopaminergic, glutamatergic and GABAergic neurotransmission, which are responsible for movement control, cognition, emotions and stress responses. Alterations of these functions, concomitant with modified brain reninangiotensin system (RAS) components, have been described in CNS pathologies like depression, Parkinson, Alzheimer, and schizophrenia. In this sense, altered functionality of angiotensin I converting enzyme and AT1 receptors, is associated with augmented susceptibility to the occurrence of these pathologies. Moreover, some epidemiological data showed lower incidence of Alzheimer disease in hypertensive patients under treatment targeting RAS; meanwhile preclinical studies relate RAS with Parkinson and depression. Little is known about schizophrenia and RAS; however, Ang II is closely related to dopamine and glutamate pathways, which are mainly altered in this pathology.

Conclusion: The available evidences, together with the results obtained by our group, open the possibility to postulate brain Ang II as a possible therapeutic target to treat the above-mentioned CNS disorders.

Keywords:

Angiotensin II, depression, Parkinson’s disease, Alzheimer's disease, schizophrenia, AT1 receptors, amphetamine sensitization.

Affiliation:

Instituto de Farmacologia Experimental Cordoba (IFEC-CONICET) Departamento de Farmacologia. Facultad de Ciencias Quimicas Universidad Nacional de Cordoba, Cordoba, Instituto de Farmacologia Experimental Cordoba (IFEC-CONICET) Departamento de Farmacologia. Facultad de Ciencias Quimicas Universidad Nacional de Cordoba, Cordoba, Instituto de Farmacologia Experimental Cordoba (IFEC-CONICET) Departamento de Farmacologia. Facultad de Ciencias Quimicas Universidad Nacional de Cordoba, Cordoba, Laboratorio de Neurofarmacologia, (IIBYT- CONICET) Universidad Nacional de Cordoba Facultad de Ciencias Quimicas, Universidad Catolica de Cordoba, Cordoba, Instituto de Farmacologia Experimental Cordoba (IFEC-CONICET) Departamento de Farmacologia. Facultad de Ciencias Quimicas Universidad Nacional de Cordoba - Cordoba

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