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The Angiotensin Converting Enzyme 2 (ACE2), Gut Microbiota, and Cardiovascular Health

[ Vol. 24 , Issue. 9 ]

Author(s):

Joao Marcus Oliveira Andrade*, Deborah de Farias Lelis, Valeria Mafra and Junio Cota   Pages 827 - 832 ( 6 )

Abstract:


Background: The renin-angiotensin system (RAS) is an important enzymatic system responsible for the regulation of biological functions, such as the arterial pressure, hydroelectrolytic control, vascular vasodilatation/vasoconstriction and more recently metabolic functions.

Objectives: The aim of the present review is to discuss the associations between the gut microbiome and the renin-angiotensin system and the influence of their intimate relationship on the cardiovascular health.

Methods: A literature review of the main studies published regarding the relationship among the renin-angiotensin system, gut microbiota and cardiovascular health was performed.

Results: The association between the ACE2 and gut microbiota has been discussed. It is shown that the ACE2/Ang 1-7 axis modulates the immune response, influencing the microbiota composition, and thus being one of the causes for some diseases physiophatologies, such as diarrhea and intestinal inflammatory disease.

Conclusion: The association between RAS and gut microbiota seems to have a strong influence on the genesis of cardiovascular diseases, through direct mechanisms, such as nerve stimulation, or indirectly on metabolic parameters, such as weight, adiposity and lipid profile.

Keywords:

Renin-angiotensin system, Angiotensin converting enzyme 2, gut microbiota, cardiovascular health, biological functions, immune response.

Affiliation:

Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, MG, Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, MG, Instituto Federal do Norte de Minas Gerais (IFNMG), Januaria, MG, Institute of Agricultural Sciences (ICA), Universidade Federal de Minas Gerais (UFMG), Montes Claros, MG

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