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Effects of Sleeve Gastrectomy on the Metabolic Profile and on the Expression of Renin-Angiotensin System in Adipose Tissue of Obese Rats

[ Vol. 24 , Issue. 9 ]

Author(s):

Thaisa Soares Crespo*, Joao Marcus Oliveira Andrade, Alanna Fernandes Paraiso, Deborah de Farias Lelis, Pablo Vinicyus Ferreira Chagas, Antonio Sergio Barcala Jorge, Wagner Leite Ferreira, Alfredo Mauricio Batista de Paula, Andre Luiz Sena Guimaraes and Sergio Henrique Sousa Santos*   Pages 861 - 868 ( 8 )

Abstract:


Background: Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity.

Objectives: The present study aimed to assess the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet.

Methods: Male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated.

Results: SG led to weight loss, decreased adiposity (p < 0.01) and a reduction in plasma glucose (p < 0.05), C-peptide (p < 0.05), insulin (p < 0.001) and total cholesterol (p < 0.05) levels. In addition, SG led to a decrease in the expression of tumor necrosis factor-alpha (TNF-α) (p < 0.01), interleukin- 6 (IL-6) (p < 0.001), angiotensinogen (AGT) (p < 0.001) and angiotensin converting enzyme (ACE) (p < 0.05) and increased the expression of angiotensin converting enzyme 2 (ACE2) (p < 0.05) in white adipose tissue. No statistically significant differences were observed for AT1 (p = 0.10) and Mas (p = 0.22) receptors.

Conclusion: This study showed that SG leads to weight loss and improves metabolic parameters. Changes in the expression of RAS components and of inflammatory molecules in adipose tissue seem to play a role the before beneficial effects of the SG.

Keywords:

Obesity, bariatric surgery, inflammation, renin-angiotensin system, metabolism, sleeve gastrectomy.

Affiliation:

Laboratory of Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil; Avenida Cula Mangabeira, 562 – Candida Camara, 39.401-696, Montes Claros, MG, Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Department of Surgery, Hospital Santa Casa – Irmandade Nossa Senhora Merces, Montes Claros, Minas Gerais, Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Institute of Agricultural Sciences. Food Engineering College, Universidade Federal de Minas Gerais (UFMG); Avenida Universitaria, 1.000 – Universitario, 39.404-547, Montes Claros, MG

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