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Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma

[ Vol. 24 , Issue. 9 ]

Author(s):

Carlos Alberto de Carvalho Fraga, Lucyana Conceicao Farias, Kimberly Marie Jones, Alfredo Mauricio Batista de Paula and Andre Luiz Sena Guimaraes*   Pages 784 - 792 ( 9 )

Abstract:


Introduction: The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer.

Objective: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia, specifically for Oral Squamous Cell Carcinoma (OSCC).

Conclusion: The literature review and Bioinformatics analyses showed that ACE and ACE2 are interesting targets for OSCC treatment. Studies involving RAS and OSCC should be encouraged for experimental validation.

Keywords:

Head and neck cancer, obesity, Angiogenesis, ACE, Ang 1-7, angiotensin-converting enzyme.

Affiliation:

Department of Medicine Universidade Federal de Alagoas, Arapiraca, Alagoas, Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Dean of Research, Unica Educacional, Montes Claros, Montes Claros, Minas Gerais, Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Universidade Estadual de Montes Claros. Hospital Universitario Clemente Faria. Laboratorio de Pesquisa em Saude, 562 Av. Cula Mangabeira Santo Expedito. Montes Claros, MG

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