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Multi-functional Chimeric Peptides: The More the Merrier

Author(s):

Anamika Singh* and Ved Srivastava   Pages 1 - 11 ( 11 )

Abstract:


Peptides are recognized as highly specific and efficacious molecules, and thus have gained recognition as therapeutics in the recent years. In contrast to the monotherapy, multi-target combination therapy that includes two or more drugs with the complementary mechanism of action are proven to be efficacious in complex pathophysiological conditions. However, combining various drugs lead to complex pharmacokinetic and pharmacodynamic profile and pose safety risks. Herein, we reviewed the therapeutic potential of multifunctional chimeric peptides with examples from the field of metabolic, cardiovascular and neuropathic pain disease.

Keywords:

peptides, chimeric peptides, multi-functional peptides

Affiliation:

Intarcia Therapeutics, Inc. Durham, Intarcia Therapeutics, Inc. Durham



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