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Bromotryptophan and its Analogs in Peptides from Marine Animals

[ Vol. 26 , Issue. 4 ]

Author(s):

Elsie C. Jimenez*   Pages 251 - 260 ( 10 )

Abstract:


Bromotryptophan is a nonstandard amino acid that is rarely incorporated in ribosomally synthesized and post-translationally modified peptides (ribosomal peptides). Bromotryptophan and its analogs sometimes occur in non-ribosomal peptides. This paper presents an overview of ribosomal and non-ribosomal peptides that are known to contain bromotryptophan and its analogs. This work further covers the biological activities and therapeutic potential of some of these peptides.

Keywords:

Bromotryptophan and analogs, nonstandard amino acid, proteinogenic and non-proteinogenic amino acids, bromotryptophan- containing peptide, ribosomal and non-ribosomal peptides, conotoxin/conopeptide.

Affiliation:

Department of Physical Sciences, College of Science, University of the Philippines Baguio, Baguio City 2600

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