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Beneficial Effects of the Angiotensin-Converting Enzyme 2 Activator Dize in Renovascular Hypertension

Author(s):

Lucas Miranda Kangussu, Tatiane Cristine S. de Almeida, Thiago Ruiz R. Prestes, Marilda Luz de Andrade De Maria, Roberta da Silva Filha, Maria Aparecida Ribeiro Vieira, Ana Cristina Simões e Silva and Anderson José Ferreira*   Pages 1 - 9 ( 9 )

Abstract:


Background: Angiotensin converting enzyme (ACE) 2 is an important modulator of the renin angiotensin system (RAS) and the RAS plays a central role in renovascular hypertension. Very few studies investigated the role of components of the counterregulatory RAS axis (ACE2, Ang-(1-7) and Mas receptor) in renovascular hypertension and the results are controversial.

Objective: The aim of this study was to investigate the effects of diminazene aceturate (DIZE) administration on renal function and renal inflammation parameters in 2K1C hypertensive rats.

Methods: Male Wistar rats were divided into three experimental groups: sham-operated animals, 2K1C+saline and 2K1C+DIZE orally (1 mg/kg/day). At the end of the 30 days of treatment, renal function was analyzed and kidneys from all the groups were collected and processed separately for measurement of N-acetyl-beta-D-glucosaminidase (NAG) and myeloperoxidase (MPO) activities, cytokines, chemokines and nitric oxide levels.

Results: Oral DIZE administration for 4 weeks in hypertensive rats attenuated renal dysfunction and reduced the levels of MPO and NAG, cytokines and chemokines (IL1β, IL-6, TNF-α and MCP-1) and increased urinary nitrate/nitrite levels in 2K1C hypertensive rats.

Conclusion: Our findings showed that ACE2 activation may effectively improve renal alterations and inflammation induced by renovascular hypertension.

Keywords:

ACE2 activation, Diminazene aceturate, Angiotensin-(1-7), Renoprotection, Renovascular hypertension.

Affiliation:

Department of Morphology – Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Morphology – Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Pediatrics – School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Morphology – Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Pediatrics – School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Physiology and Biophysics – Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Pediatrics – School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Morphology – Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG



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