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Beneficial Effects of the Angiotensin-Converting Enzyme 2 Activator Dize in Renovascular Hypertension

[ Vol. 26 , Issue. 7 ]

Author(s):

Lucas Miranda Kangussu*, Tatiane Cristine S. de Almeida, Thiago Ruiz R. Prestes, Marilda Luz de Andrade De Maria, Roberta da Silva Filha, Maria Aparecida Ribeiro Vieira, Ana Cristina Simões e Silva and Anderson José Ferreira*   Pages 523 - 531 ( 9 )

Abstract:


Background: Angiotensin Converting Enzyme (ACE) 2 is an important modulator of the Renin Angiotensin System (RAS) and the RAS plays a central role in renovascular hypertension. Very few studies investigated the role of components of the counterregulatory RAS axis (ACE2, Ang-(1-7) and Mas receptor) in renovascular hypertension and the results are controversial.

Objective: The aim of this study was to investigate the effects of Diminazene Aceturate (DIZE) administration on renal function and renal inflammation parameters in 2K1C hypertensive rats.

Methods: Male Wistar rats were divided into three experimental groups: sham-operated animals, 2K1C+saline and 2K1C+DIZE orally (1 mg/kg/day). At the end of the 30 days of treatment, renal function was analyzed and kidneys from all the groups were collected and processed separately for measurement of N-acetyl-beta-D-glucosaminidase (NAG) and Myeloperoxidase (MPO) activities, cytokines, chemokines and nitric oxide levels.

Results: Oral DIZE administration for 4 weeks in hypertensive rats attenuated renal dysfunction and reduced the levels of MPO and NAG, cytokines and chemokines (IL1β, IL-6, TNF-α and MCP-1) and increased urinary nitrate/nitrite levels in 2K1C hypertensive rats.

Conclusion: Our findings showed that ACE2 activation may effectively improve renal alterations and inflammation induced by renovascular hypertension.

Keywords:

ACE2 activation, diminazene aceturate, angiotensin-(1-7), renoprotection, renovascular hypertension, renin angiotensin system.

Affiliation:

Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG

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