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Directive Effect of Chain Length in Modulating Peptide Nano-assemblies

Author(s):

Gaurav Pandey, Prem Prakash Das and Vibin Ramakrishnan*   Pages 1 - 7 ( 7 )

Abstract:


RADA-4 (Ac-RADARADARADARADA-NH2) is the most extensively studied and marketed self- assembling peptide, forming hydrogel, used to create defined three-dimensional microenvironments for cell culture applications. In this work, we use various biophysical techniques to investigate the length dependency of RADA aggregation and assembly. We synthesized a series of RADA-N peptides, N ranging from 1 to 4, resulting in four peptides having 4, 8, 12, and 16 amino acids in their sequence. Our observations show that the aggregation of ionic, charge-complementary RADA motif-containing peptides is length-dependent, with N less than 3 are not forming spontaneous self-assemblies.

Keywords:

Functional peptides, Nanofibers, Peptide self-assembly, RADA peptide

Affiliation:

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039



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