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Biomarkers of Acromegaly and Growth Hormone Action

Author(s):

Filippo Maffezzoni, Teresa Porcelli, Andrea Delbarba, Letizia Pezzaioli, Carlo Cappelli and Alberto Ferlin*   Pages 1 - 15 ( 15 )

Abstract:


Biological markers (biomarkers) play a key role in drug development, regulatory approval and clinical care of patients and are linked to clinical and surrogate outcomes. Both acromegaly and growth hormone deficiency (GHD) are pathological conditions related to important comorbidities that, in addition to having stringent diagnostic criteria, require valid markers for the definition of treatment, treatment monitoring and follow-up. GH and insulin-like growth factor-I (IGF-I) are the main biomarkers of GH action in children and adults while, in acromegaly, both GH and IGF-I are established biomarkers of disease activity. However, although GH and IGF-I are widely validated biomarkers of GHD and acromegaly, their role is not completely exhaustive or suitable for clinical classification and follow-up. Therefore, new biological markers for acromegaly and GH replacement therapy are strongly needed. The aim of this paper is to review and summarize the current state in the field pointing out new potential biomarkers for acromegaly and GH use/abuse.

Keywords:

Acehytisine hydrochloride, anti-arrhythmic drugs, cancer, hERG, QSAR, van der Waals, Growth hormone, miRNA, acromegaly, GH deficit, biomarkers, insulin-like growth factor-I.

Affiliation:

Unit of Endocrinology and Metabolism, Department of Medicine, ASST Spedali Civili Brescia, Brescia, Endocrinology, Montichiari Hospital, ASST Spedali Civili Brescia, Montichiari, Unit of Endocrinology and Metabolism, Department of Medicine, ASST Spedali Civili Brescia, Brescia, Department of Clinical and Experimental Sciences, Unit of Endocrinology and Metabolism, Brescia, Department of Clinical and Experimental Sciences, Unit of Endocrinology and Metabolism, Brescia, Department of Clinical and Experimental Sciences, Unit of Endocrinology and Metabolism, Brescia



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