Tsun-Thai Chai*, Kah-Yaw Ee, D. Thirumal Kumar, Fazilah Abd Manan and Fai-Chu Wong Pages 623 - 642 ( 20 )
Large numbers of bioactive peptides with potential applications in protecting against human diseases have been identified from plant sources. In this review, we summarized recent progress in the research of plant-derived bioactive peptides, encompassing their production, biological effects, and mechanisms. This review focuses on antioxidant, antimicrobial, antidiabetic, and anticancer peptides, giving special attention to evidence derived from cellular and animal models. Studies investigating peptides with known sequences and well-characterized peptidic fractions or protein hydrolysates will be discussed. The use of molecular docking tools to elucidate inter-molecular interactions between bioactive peptides and target proteins is highlighted. In conclusion, the accumulating evidence from in silico, in vitro and in vivo studies to date supports the envisioned applications of plant peptides as natural antioxidants as well as health-promoting agents. Notwithstanding, much work is still required before the envisioned applications of plant peptides can be realized. To this end, future researches for addressing current gaps were proposed.
Anticancer, antidiabetic, antimicrobial, antioxidant, bioactive peptide, molecular docking.
Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900, Center for Biodiversity Research, Universiti Tunku Abdul Rahman, Kampar 31900, Department of Bioinformatics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai 602 105, Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor, Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900