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Structural Phylogeny of Different Allergens May Reveal Common Epitopic Footprint

[ Vol. 28 , Issue. 10 ]

Author(s):

Anubhab Laha, Anindya Sundar Panja and Rajib Bandopadhyay*   Pages 1099 - 1107 ( 9 )

Abstract:


Background: The incidence of allergy has been increasing at an alarming rate over the last few decades.

Objective: Our present study aims to find out the structurally homologous motifs present in different proteinaceous allergens.

Methods: Significant number of protein sequences and their corresponding structures of various pollen, fungal, bacterial, and food allergens were retrieved and the sequence and structural identity were analyzed.

Results: Intra- and inter-sequence along with their structural analysis of the proteinaceous allergens revealed that no significant relationships exist among them. A few, but not the negligible number of high structural similarities, were observed within different groups of allergens from fungus, angiosperms, and animals (Aves and Mammalia).

Conclusion: Our in silico study on thirty-six different allergens showed a significant level of structural similarities among themselves, regardless of their sequences.

Keywords:

Allergy, allergen, epitope, hypersensitivity, structural homology, protein sequences.

Affiliation:

UGC Centre for Advanced Study, Department of Botany, The University of Burdwan, Golapbag, Burdwan – 713104, West Bengal, Department of Biotechnology and Biochemistry, Oriental Institute of Science and Technology, Burdwan, West Bengal, UGC Centre for Advanced Study, Department of Botany, The University of Burdwan, Golapbag, Burdwan – 713104, West Bengal



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