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Thymic Immunosuppressive Pentapeptide (TIPP) Shown Anticancer Activity in Breast Cancer and Chronic Myeloid Leukemia Both In Vitro and In Vivo

Author(s):

Muhammad Ijaz, Muhammad Shahbaz, Wenjie Jiang, Yikang Shi, Xiuli Guo* and Fengshan Wang*   Pages 1 - 9 ( 9 )

Abstract:


Aim: Being the common cause and major burden of deaths globally, timely cancer management is crucial.

Background: Thymic immunosuppressive pentapeptide (TIPP) is a novel pentapeptide originally obtained from calf thymic immunosuppressive extract. Previously, TIPP has been proved to suppress the allergic and inflammatory responses in allergic mice via blocking MAP kinases/NF-κB signaling pathways.

Objective: In this study, in vitro anticancer activity of TIPP was tested on two different types of cancers using MCF-7 and K562 cell lines.

Methods: Tumor xenograft models for breast cancer and chronic myeloid leukemia were designed. In vivo anticancer activity of TIPP was investigated on both cancer types. The liver and tumor tissues of the mice were preserved for immunohistochemistry analysis.

Results: In vitro anticancer activity of TIPP showed significant inhibition on cell viability of both breast cancer and chronic myeloid leukemia. In vivo anticancer effect of TIPP in both types of cancer models further proved the potent anticancer nature of TIPP. Immunohistochemistry analysis assured that TIPP is a safe drug for normal organs such as the liver.

Conclusion: Our present study revealed that TIPP is a potent anticancer drug and an important treatment option for various diseases. Further work is needed to test the flexible and proficient activity of the novel peptide.

Keywords:

Cancer, breast cancer, chronic myeloid leukemia, thymic immunosuppressive pentapeptide (TIPP), immunohistochemistry, anticancer drug.

Affiliation:

Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, No.44 Wenhuaxi Road, Jinan 250012, Department of General Surgery, Qilu Hospital affiliated to Shandong University, No.107 Wenhuaxi Road, Jinan 250012, P.R.China. . Research Center for Sectional and Imaging Anatomy, Digital Human Institute, School of Basic Medical Sciences, Shandong University, 250012, Jinan, Shandong, Department of Chemistry, University of Florida, Gainesville, FL 32611, Department of Pharmacology, Shandong University, No.44 Wenhuaxi Road, Jinan 250012, Department of Pharmacology, Shandong University, No.44 Wenhuaxi Road, Jinan 250012, Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, No.44 Wenhuaxi Road, Jinan 250012



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