Submit Manuscript  

Article Details


Microbial Cold Shock Proteins: Overview of their Function and Mechanism of Action

Author(s):

Yonghong Zhang, Changjie Bao, Lijun Shen, Chunjie Tian, Xueli Zang, Sitong Zhang* and Guang Chen*  

Abstract:


The organism responds to a decrease in temperature by producing a series of cold shock proteins (CSPs). These proteins play a critical role in growing and functioning characteristic at low temperatures. CSPs have been discovered in a wide range of organisms and show enormous diversity; their mechanisms of action are also complicated. Transcription and translation in microorganisms typically occur via a single linear chain, but upon exposure to low temperatures, RNA forms a complex secondary structure that prevents ribosomes from binding to it, slowing down translation. CSPs bind to mRNA as RNA molecular chaperones to keep the mRNA secondary structure in a single-stranded linear conformation, allowing successful translation at low temperatures.

Keywords:

cold shock protein, transcription, translation, csp mRNA, 5'-UTR, RNA chaperone

Affiliation:

College of Life Sciences, Jilin Agricultural University, Changchun, College of Life Sciences, Jilin Agricultural University, Changchun, College of Life Sciences, Jilin Agricultural University, Changchun, Key Laboratory of Mollisols Agroecology, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, School of Medicine and Food, Changchun Medical College, Changchun, College of Life Sciences, Jilin Agricultural University, Changchun, College of Life Sciences, Jilin Agricultural University, Changchun



Full Text Inquiry