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Design and Synthesis of Metal-Free Artificial Ribonucleases

[ Vol. 14 , Issue. 2 ]

Author(s):

Ludmila S. Koroleva, Inna Yu. Serpokrylova, Valentin V. Vlassov and Vladimir N. Silnikov   Pages 151 - 163 ( 13 )

Abstract:


The present review is aimed at giving a general overview of our results in the field of designing and synthesizing simple peptide-like molecules that mimic structural and functional aspects of natural ribonucleases, as well as designing oligonucleotide-based artificial ribonucleases.

Keywords:

Artificial ribonucleases, RNases mimics, oligonucleotide conjugates

Affiliation:

Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentiev prosp., Novosibirsk, 630090,Russia.



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