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Synthesis and Biological Evaluation of N-Phosphoryl Dipeptide Derivatives as Potent Apoptosis Inducers

[ Vol. 15 , Issue. 4 ]


Xiaoqing Yu, Chunyan Tan, Nan Zhang, Wei Xu and Yuyang Jiang   Pages 356 - 359 ( 4 )


A series of N-phosphoryl dipeptide derivatives with trimethoxyaniline moiety were synthesized, in which compound 2a DIPP-Val-Phe-Ar exhibited the best inhibitory activity against K562 cells with the IC50 at 9.7 μM. Its antitumor effects are due to the induction of apoptosis which was further confirmed by morphological study and flow cytometry analysis.


N-phosphoryl dipeptide derivative, antitumor, apoptosis


Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055 P.R. China.

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