Submit Manuscript  

Article Details


The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands

[ Vol. 16 , Issue. 7 ]

Author(s):

A. Hanna-Elias, P. E. Thompson, D. T. Manallack, H. R. Irving, I. M. Coupar, I. Berque-Bestel and M. N. Iskander   Pages 805 - 809 ( 5 )

Abstract:


A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further synthetic work.

Keywords:

Serotonin, 5-HT, 5-HT4, tripeptide, molecular docking, radioligand binding

Affiliation:

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Vic. 3052, Australia.



Read Full-Text article