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The Two Pathways for Effective Orthogonal Protection of L-Ornithine, for Amino Acylation of 5-O-Pivaloyl Nucleosides, Describe the General and Important Role for the Successful Imitation, During the Synthesis of the Model Substrates for the Ribosomal Mimic Reaction

[ Vol. 17 , Issue. 7 ]

Author(s):

Stanislav G. Bayryamov, Nikolay G. Vassilev and Dimiter D. Petkov   Pages 889 - 898 ( 10 )

Abstract:


Bz(NO2)-Orn(Boc)-OCH2CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide synthesis and modification of amino acids.

Keywords:

Conventional peptide synthesis, orthogonal protection, ornithine

Affiliation:

Laboratory of BioCatalysis, Institute of Organic Chemistry, Bulgrian Academy of Sciences, Acad. Bonchev Str., bld. 9, 1113 Sofia, Bulgaria.



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