Muhammad T. Islam*, Eunus S. Ali, Shaikh J. Uddin, Ishaq N. Khan, Manik C. Shill, João M. de Castro e Sousa, Marcus V.O. Barros de Alencar, Ana A.C. Melo-Cavalcante and Mohammad S. Mubarak* Pages 536 - 547 ( 12 )
<P>Background: Centilla asiatica L is a medicinal herb that has been widely used in folk medicine to treat various diseases. Asiatic Acid (AA), a triterpene and a known component of this herb, has been shown to display important biological activities, including anti-inflammatory, antibacterial, antidiabetic and antihyperlipidemic, neuroprotective, anxiolytic and antidepressant, hepatoprotective, pancreas protective, and cardio- protective. </P><P> Objective: This review focuses on AA’s anti-cancer effects on the basis of published literature found in a number of databases such as PubMed and Science Direct. Emphasis has been given to the mechanisms of action of its anti-cancer effect. </P><P> Methods: A literature survey was conducted using known databases such as PubMed and Science Direct using the keywords ‘Asiatic acid’, pairing with ‘cancer’, ‘tumor’, ‘anti-cancer effect’, ‘cytotoxic effect’, ‘anti-tumor activity’, ‘cell line’, ‘animal cancer’, and ‘human cancer’. </P><P> Results: Findings suggest that AA exerts anti-cancer effects in several test systems through various pathways, including oxidative/antioxidant, anti-inflammatory, cytotoxicity, apoptotic cell death, necrosis, anti-angiogenesis, inhibition of proliferation and cell migration, and chemoprevention. </P><P> Conclusion: AA may be an effective plant-based cancer chemotherapeutic agent and a promising lead for the development of potent anticancer drugs.</P>
Asiatic acid, Centilla asiatica, cancer, mechanisms of action, chemotherapeutic agent, anticancer drugs.
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, Gaco Pharmaceuticals Limited, Dhaka-1000, Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, 25000, Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka, 1229, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina, 64 049-550, Department of Biological Sciences, Federal University of Piauí, Picos, Piauí, 64 067-670, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina, 64 049-550, Department of Chemistry, The University of Jordan, Amman 11942