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Invertebrate FMRFamide Related Peptides

[ Vol. 20 , Issue. 6 ]


Kevin G. Krajniak   Pages 647 - 670 ( 24 )


In 1977 the neuropeptide FMRFamide was isolated from the clam, Macrocallista nimbosa. Since then several hundred FMRFamide-related peptides (FaRPs) have been isolated from invertebrate animals. Precursors to the FaRPs likely arose in the cnidarians. With the transition to a bilateral body plan FaRPs became a fixture in the invertebrate phyla. They have come to play a critical role as neurotransmitters, neuromodulators, and neurohormones. FaRPs regulate a variety of body functions including, feeding, digestion, circulation, reproduction, movement. The evolution of the molecular form and function of these omnipresent peptides will be considered.


FMRFamide, FaRPs, cnidaria, platyhelminthes, nematoda, annelida, mollusca, arthropoda.


Department of Biological Sciences, Southern Illinois University Edwardsville, Illinois Box 1651, Edwardsville, IL 62026-1651, USA.

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