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Metformin Ameliorates Neuronal Necroptosis after Intracerebral Hemorrhage by Activating AMPK

[ Vol. 18 , Issue. 3 ]

Author(s):

Chenhan Lin , Kaichuang Yang, Guoqiang Zhang and Jun Yu*   Pages 351 - 359 ( 9 )

Abstract:


Background: Intracerebral hemorrhage (ICH) is a major cause of death and disability globally. As a type of secondary injury after ICH, treatment for cell death can promote the recovery of neurological function. <p> Methods: Among all the cell death, neuronal necroptosis has recently been demonstrated of significance in the pathogenesis of ICH. However, the administration of drugs against necroptosis has many limitations. <p> Results: In the present study, we found that metformin, a first-line medication for the treatment of type 2 diabetes, can effectively inhibit neuronal necroptosis after ICH by activating the AMPK related pathway, thereby significantly improving neurological function scores and reducing brain edema. <p> Conclusion: These results will provide a new perspective for future research in necroptosis.

Keywords:

ICH, necroptosis, metformin, AMPK, rotarod test, western blot analysis.

Affiliation:

Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, Department of Neurosurgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang



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