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The Renin Angiotensin System and Bipolar Disorder: A Systematic Review

[ Vol. 27 , Issue. 6 ]

Author(s):

Izabela Guimarães Barbosa*, Giulia Campos Ferreira, Diomildo Ferreira Andrade Júnior , Cássio Rocha Januário, André Rolim Belisário, Moises Evandro Bauer and Ana Cristina Simões e Silva   Pages 520 - 528 ( 9 )

Abstract:


Bipolar Disorder (BD) is a chronic a multifactorial psychiatric illness that affects mood, cognition, and functioning. BD is associated with several psychiatric conditions as well clinical comorbidities, particularly cardiovascular diseases. The neurobiology of BD is complex and multifactorial and several systems have been implicated. Considering that the Renin Angiotensin System (RAS) plays an important role in cardiovascular diseases and that recently evidence has suggested its role in psychiatric disorders, the aim of the present study is to summarize and to discuss recent findings related to the modulation of RAS components in BD. A systematic search of the literature using the electronic databases MEDLINE and LILACS was conducted through March 2019. The search terms were: “Bipolar Disorder”; “Renin Angiotensin System”; “Angiotensin 2”; “Angiotensin receptors”; “Angiotensin 1-7”; “ACE”; “ACE2”; “Mas Receptor”. We included original studies assessing RAS in BD patients. Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. In the majority of studies (6 of 8), the ACE insertion/deletion (I/D) polymorphism did not differ between BD patients and controls. BD patients presented higher plasma renin activity in comparison with controls. The studies evaluating the RAS molecules in BD are very scarce and heterogeneous. The literature suggests a potential role of RAS in BD. Further studies are necessary to investigate this relationship.

Keywords:

Renin angiotensin system, angiotensin peptides, bipolar disorder, mania, depression, plasma renin activity.

Affiliation:

Interdisciplinary Laboratory of Medical Investigation - Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Interdisciplinary Laboratory of Medical Investigation - Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Interdisciplinary Laboratory of Medical Investigation - Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Interdisciplinary Laboratory of Medical Investigation - Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Interdisciplinary Laboratory of Medical Investigation - Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Laboratory of Immunosenescence, Graduate Program in Biomedical Gerontology, School of Sciences, Pontifícia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, Interdisciplinary Laboratory of Medical Investigation - Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG

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