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New Derivatives of Picolinic Acid and Nicotinic Acid with Anticonvulsant Activity

[ Vol. 12 , Issue. 7 ]

Author(s):

Ryszard Paruszewski, Marzanna Strupinska, Grazyna Rostafinska-Suchar and James P. Stables   Pages 701 - 704 ( 4 )

Abstract:


Previously obtained Pic-BZA is a potent anticonvulsant with low neurotoxicity, but its half-time of action is only about 15 min. In search for equally effective anticonvulsants but with a longer time of action fourteen Pic-BZA analogs were obtained. The compounds were evaluated in the Anticonvulsant Screening Project (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH. Picolinic acid 2-fluorobenzylamide (Pic-2-F-BZA, 7) appeared to be the most effective compound of the series.

Keywords:

anticonvulsant, activity, neurotoxicity, time of action, picolinic acid, nicotinic acid

Affiliation:

Department of DrugChemistry, Medical University, 02-097 Warszawa, Poland;



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