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Protein Folding, Misfolding and Aggregation: Evolving Concepts and Conformational Diseases

[ Vol. 12 , Issue. 3 ]

Author(s):

Carlos H.I. Ramos and Sergio T. Ferreira   Pages 213 - 222 ( 10 )

Abstract:


Proteins carry out many vital cellular functions determined by their precise 3-dimensional structures (the native conformations). Understanding how proteins fold has long been a major goal and can be of great therapeutic value. Failure to reach or maintain the correct folded structure can have serious consequences, as in the conformational diseases. The ultimate goal of folding studies is to predict structure from sequence, allowing the design of new functional proteins and prevention of aberrant disease-associated conformations.

Keywords:

protein folding, misfolding, aggregation, amyloid, amyloidoses

Affiliation:

Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, PO Box 6192, Campinas SP 13084-971, Brazil.



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