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Protein Folding Cooperativity: Basic Insights from Minimalist Models

[ Vol. 12 , Issue. 3 ]


Antonio F. Pereira de Araujo   Pages 223 - 228 ( 6 )


Basic concepts about two-state, cooperative protein folding and its relation to first-order phase transitions are reviewed. Minimalist models capable of reproducing the required free energy barrier between folded and unfolded macroscopic states are described. A significantly more restrictive “calorimetric” criterion is also discussed, which is based on direct comparison between model and experimental heat capacities with additional assumptions about conformational enthalpy variation in the unfolded state.


lattice model, cooperativity, two-state transition, hydrophobicity, hydrogen bond, structural segregation, first-order phase transition


Departamento de Biologia Celular Universidade de Brasília, Brasília-DF 70910-900, Brazil.

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