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High Pressure Studies on Transthyretin

[ Vol. 12 , Issue. 3 ]

Author(s):

Debora Foguel   Pages 245 - 249 ( 5 )

Abstract:


High hydrostatic pressure (HHP) is a powerful tool to study protein folding and the dynamics and structure of folding intermediates. Aggregates and amyloids, derived from partially folding intermediates at the junction between productive and off-pathway folding, have been studied as well, which promises better understanding of the protein misfolding diseases. Here is summarized the recent data we have collected with transthyretin under pressure.

Keywords:

high hydrostatic pressure, amyloidogenic diseases, protein folding, protein aggregation, transthyretin

Affiliation:

Departamento de Bioquimica Medica, Programa de Biologia estrutural, Instituto de Ciencias Biomedicas,Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-590, Brazil.



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