Submit Manuscript  

Article Details


The Hypothesis of the Catalytic Action of Nucleic Acid on the Conversion of Prion Protein

[ Vol. 12 , Issue. 3 ]

Author(s):

Yraima Cordeiro and Jerson L. Silva   Pages 251 - 255 ( 5 )

Abstract:


The main hypothesis for prion diseases proposes that the cellular protein (PrPC) can be altered into a misfolded, β-sheet-rich isoform (PrPSc). We describe here that host nucleic acid may catalyze the conversion between PrPC and PrPSc isoforms, by reducing the protein mobility and by making the protein-protein interactions more likely. We summarize the findings, focusing in the biological relevance of the catalytic action of nucleic acid.

Keywords:

prion, structural conversion, nucleic acid, catalysis, aggregation

Affiliation:

Departamento de Bioquimica Medica, Centro Nacional de Ressonancia Magnetica Nuclear de Macromoleculas, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, RJ 21941-590, Brazil.



Read Full-Text article