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Proliferative Activity Of Neokyotorphinrelated Hemoglobin Fragments In Cell Cultures

[ Vol. 10 , Issue. 4 ]

Author(s):

Olga V. Sazonova, Elena Yu. Blishchenko, Olga A. Kalinina, Natalya S. Egorova, Andrei Yu. Surovoy, Marina M. Philippova, Andrei A. Karelin and Vadim T. Ivanov   Pages 386 - 395 ( 10 )

Abstract:


α-Hemoglobin fragments α-(133-141), α-(134-141), α-(135-141), α-(137-141), α-(134-140), α- (133-138), α-(134-140) and α-(137-138) stimulate L929 tumor cell proliferation, α-(134-141) being the most active. α-(134-141) stimulates proliferation of M3 melanoma cells, murine embryonic fibroblasts, primary cultures of red bone marrow and spleen cells. In L929 cells the effect of α-(134-141) is cell density independent; in M3 cells α-(137-141) and α-(134-141) are most active at density 10,000 cells / well (96 well plate) independently on FBS content.

Keywords:

neokyotorphin, proliferation

Affiliation:

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, Miklukho-Maklaya, 16 / 10, 117871 Moscow, Russia.



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