Submit Manuscript  

Article Details


Proteomic Analysis of Mitochondria in Raji Cells Following Exposure to Radiation: Implications for Radiotherapy Response

[ Vol. 16 , Issue. 11 ]

Author(s):

Yujie Jiang, Xin Liu, Xiaosheng Fang and Xin Wang   Pages 1350 - 1359 ( 10 )

Abstract:


Radioresistance represents a major obstacle to a successful outcome for the treatment of non-Hodgkins lymphoma (NHL). Here we performed a global differential proteome analysis of the mitochondria in Raji cells exposed to radiation. The results showed that 23 differentially expressed proteins were identified. Furthermore, GAPDH, RECQL4, MKI67, and ATAD3B could serve as potential biomarkers of radioresistance.

Keywords:

Mitochondria, Comparative proteomics, Raji, Radiation, Biomarker

Affiliation:

Department of Hematology, Provincial Hospital Affiliated to Shandong University, Add: No. 324, Jingwu Road, Jinan, Shandong, 250021, China.



Read Full-Text article