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Efficient Growth Inhibition of Human Osteosarcoma Cells Using a Peptide Derived from the MDM-2-Binding Site of p53

[ Vol. 17 , Issue. 5 ]

Author(s):

R. Ito, H. Kanno, A. Takahashi, R. Matsumoto, N. Kobayashi, T. Yoshida and T. Saito   Pages 610 - 615 ( 6 )

Abstract:


Protein transduction therapy is a promising alternative to gene therapy, but has not previously been investigated for osteosarcoma. We here demonstrate efficient growth inhibition of human osteosarcoma cells using a p53 peptide. Our result suggests that protein transduction therapy has significant potential as a novel therapeutic approach for osteosarcoma.

Keywords:

Osteosarcoma, p53 peptide, protein transduction therapy, protein transduction domain, poly arginine, nuclear localization signal

Affiliation:

Department of Orthopaedic Surgery, Yokohama City University School of Medicine, Yokohama, Japan.



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