Submit Manuscript  

Article Details


Synthesis of Oligopeptides Through O-acyl Isopeptide Method

[ Vol. 18 , Issue. 8 ]

Author(s):

H. S. Lalithamba, H. P. Hemantha and Vommina V. Sureshbabu   Pages 848 - 857 ( 10 )

Abstract:


The O-acyl isopeptide method has recently gained attention as an efficient protocol for the synthesis of ‘difficult sequence‘ peptides. Herein, synthesis of three oligopeptides of different length, a pentapeptide Gly-Leu-Leu-Ser-Val, a heptapeptide fragment 285-291 of transmembrane (M7-24-T40) Ala-Val-Leu-Ser-Leu-Pro-Leu and a decapeptide, Gly- Leu-Leu-Ser-Val-Leu-Gly-Ser-Val-Ala were demonstrated in solution phase by employing O-acyl isopeptide method. The peptides were established through an efficient pH triggered intramolecular O→N acyl migration under physiological conditions. The reactions were clean and complete in appreciable length of time.

Keywords:

O-acyl isopeptide, ‘click’ peptide, O→N intramolecular acyl migration, Hydrogen bonding, pseudoproline moiety, depsi peptide, polarity, oligopeptide fragments, HPLC chromatogra, anticancer prodrugs, hassle-free peptide assembly, click peptide method, switch peptide, anhydride method, isopeptide, depsi linkage, Amino acidsO-acyl isopeptide, ‘click’ peptide, O→N intramolecular acyl migration, Hydrogen bonding, pseudoproline moiety, depsi peptide, polarity, oligopeptide fragments, HPLC chromatogra, anticancer prodrugs, hassle-free peptide assembly, click peptide method, switch peptide, anhydride method, isopeptide, depsi linkage, Amino acids

Affiliation:

Room 109, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr.B. R. Ambedkar Veedhi, Bangalore -560 001, India.



Read Full-Text article